Linked Life Data

17551517

Source:http://linkedlifedata.com/resource/pubmed/id/17551517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-6-22
pubmed:abstractText
Intermediate filaments (IFs) constitute a major structural element of animal cells. They build two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major function is assumed to be that of a mechanical stress absorber and an integrating device for the entire cytoskeleton. In line with this, recent disease mutations in human IF proteins indicate that the nanomechanical properties of cell-type-specific IFs are central to the pathogenesis of diseases as diverse as muscular dystrophy and premature ageing. However, the analysis of these various diseases suggests that IFs also have an important role in cell-type-specific physiological functions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1471-0072
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
562-73
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Intermediate filaments: from cell architecture to nanomechanics.
pubmed:affiliation
B065 Functional Architecture of the Cell, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. h.herrmann@dkfz-heidelberg.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't