|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2007-6-6
|
|
pubmed:abstractText |
Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 microM) and II (IC50: 98 microM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 microM, respectively.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0021-8820
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
309-16
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17551209-Antibiotics, Antineoplastic,
pubmed-meshheading:17551209-Bacteria,
pubmed-meshheading:17551209-Cell Line, Tumor,
pubmed-meshheading:17551209-Cell Proliferation,
pubmed-meshheading:17551209-Culture Media,
pubmed-meshheading:17551209-Depsipeptides,
pubmed-meshheading:17551209-Drug Screening Assays, Antitumor,
pubmed-meshheading:17551209-Enzyme Inhibitors,
pubmed-meshheading:17551209-Fermentation,
pubmed-meshheading:17551209-Fungi,
pubmed-meshheading:17551209-Fusarium,
pubmed-meshheading:17551209-Humans,
pubmed-meshheading:17551209-Maackia,
pubmed-meshheading:17551209-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17551209-Microbial Sensitivity Tests,
pubmed-meshheading:17551209-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:17551209-Spectrophotometry, Infrared,
pubmed-meshheading:17551209-Spectrophotometry, Ultraviolet,
pubmed-meshheading:17551209-Topoisomerase I Inhibitors,
pubmed-meshheading:17551209-Topoisomerase II Inhibitors
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Fusaristatins A and B, two new cyclic lipopeptides from an endophytic Fusarium sp.
|
|
pubmed:affiliation |
Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Japan. yshiono@tds1.tr.yamagata-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
