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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-6-15
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pubmed:abstractText |
Gabapentin is a structural analogue of gamma-aminobutyric acid with strong anticonvulsant and analgesic activities. Important discrepancies are observed on the effectiveness and potency of gabapentin in acute nociception and sensitization due to inflammation and neuropathy. There is also some controversy in the literature on whether gabapentin is only active in central areas of the nervous system or is also effective in the periphery. This is probably due to the use of different experimental models, routes of administration and types of sensitization. The aim of the present study was to investigate the influence of the spinal cord sensitization on the antinociceptive activity of gabapentin in the absence and in the presence of monoarthritis and neuropathy, using the same experimental protocol of stimulation and the same technique of evaluation of antinociception.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-10381778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-10517958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-10704997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11129121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11207393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11245671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11248535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11378164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11690735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11786502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11888243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11897114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-11906970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-12406532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-12637113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-12730275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-12750440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-12855346,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-12970103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-14499429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-14642784,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-8895246,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-9537323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-9551785,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17550605-9878876
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1742-2094
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17550605-Amines,
pubmed-meshheading:17550605-Analgesics,
pubmed-meshheading:17550605-Animals,
pubmed-meshheading:17550605-Cyclohexanecarboxylic Acids,
pubmed-meshheading:17550605-Dose-Response Relationship, Drug,
pubmed-meshheading:17550605-Hyperalgesia,
pubmed-meshheading:17550605-Male,
pubmed-meshheading:17550605-Pain Measurement,
pubmed-meshheading:17550605-Rats,
pubmed-meshheading:17550605-Rats, Wistar,
pubmed-meshheading:17550605-Spinal Cord,
pubmed-meshheading:17550605-gamma-Aminobutyric Acid
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pubmed:year |
2007
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pubmed:articleTitle |
The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia.
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pubmed:affiliation |
Departamento de Fisiología, Campus Universitario, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. mar.curros@uah.es <mar.curros@uah.es>
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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