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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-27
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pubmed:abstractText |
The skeletal phenotype of the cav-1(-/-) mouse, which lacks caveolae, was examined. muCT and histology showed increased trabecular and cortical bone caused by the gene deletion. Structural changes were accompanied by increased mechanical properties. Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0884-0431
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pubmed:author |
pubmed-author:AlemanMariaM,
pubmed-author:BoyanBarbara DBD,
pubmed-author:CaseNatashaN,
pubmed-author:DrabMarcusM,
pubmed-author:FanXianX,
pubmed-author:GrossTed STS,
pubmed-author:JoHanjoongH,
pubmed-author:RubinJanetJ,
pubmed-author:SchwartzZviZ,
pubmed-author:SenBuerB,
pubmed-author:SmithDeborahD,
pubmed-author:WongKevin LKL,
pubmed-author:YaoHaiH
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1408-18
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pubmed:dateRevised |
2011-4-29
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pubmed:meshHeading |
pubmed-meshheading:17550335-Animals,
pubmed-meshheading:17550335-Biomechanics,
pubmed-meshheading:17550335-Bone and Bones,
pubmed-meshheading:17550335-Caveolin 1,
pubmed-meshheading:17550335-Gene Silencing,
pubmed-meshheading:17550335-Mice,
pubmed-meshheading:17550335-Mice, Inbred C57BL,
pubmed-meshheading:17550335-Mice, Knockout,
pubmed-meshheading:17550335-Osteoblasts
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pubmed:year |
2007
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pubmed:articleTitle |
Caveolin-1 knockout mice have increased bone size and stiffness.
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pubmed:affiliation |
Department of Medicine,University of North Carolina, Chapel Hill, North Carolina 27599, USA. janet_rubin@med.unc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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