Linked Life Data

17548800

Source:http://linkedlifedata.com/resource/pubmed/id/17548800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-1-29
pubmed:abstractText
Layer 5 (L5) of somatosensory cortex is a major gateway for projections to intra- and subcortical brain regions. This layer is further divided into 5A and 5B characterized by relatively separate afferent and efferent connections. Little is known about the organization of connections within L5A of neocortical columns. We therefore used paired recordings to probe the anatomy and physiology of monosynaptic connections between L5A pyramidal neurons within the barrel columns of somatosensory cortex in acute slices of approximately 3-week-old rats. Post hoc reconstruction and calculation of the axodendritic overlap of pre- and postsynaptic neurons, together with identification of putative synaptic contacts (3.5 per connection), indicated a preferred innervation domain in the proximal dendritic region. Synaptic transmission was reliable (failure rate <2%) and had a low variability (coefficient of variation of 0.3). Unitary excitatory postsynaptic potential (EPSP) amplitudes varied 30-fold with a mean of 1.2 mV and displayed depression over a wide range of frequencies (2-100 Hz) during bursts of presynaptic firing. A single L5A pyramidal neuron was estimated to target approximately 270 other pyramidal neurons within the same layer of its home barrel column, suggesting a mechanism of feed-forward excitation by which synchronized single action potentials are efficiently transmitted within L5A of juvenile cortex.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1460-2199
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-406
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortex.
pubmed:affiliation
Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, D-69120 Heidelberg, Germany. andreas.frick@mpimf-heidelberg.mpg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't