Linked Life Data

17548696

Source:http://linkedlifedata.com/resource/pubmed/id/17548696

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-6-5
pubmed:abstractText
We conducted a case-control study to investigate interindividual variability in susceptibility to health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and their interaction. A total of 594 cases of arsenic-induced skin lesions and 1,041 controls was selected from baseline participants in a large prospective cohort study in Bangladesh. Adjusted odds ratios (OR) for skin lesions were estimated in relation to the polymorphisms in the glutathione S-transferase omega1 and methylenetetrahydrofolate reductase genes, the percentage of monomethylarsonous acid (%MMA) and dimethylarsinic acid (%DMA) in urine, and the ratios of MMA to inorganic arsenic and DMA to MMA. Water arsenic concentration was positively associated with %MMA and inversely associated with %DMA. The dose-response relationship of risk of skin lesion with %MMA was more apparent than those with other methylation indices; the ORs for skin lesions in relation to increasing %MMA quartiles were 1.00 (reference), 1.33 [95% confidence interval (95% CI), 0.92-1.93], 1.68 (95% CI, 1.17-2.42), and 1.57 (95% CI, 1.10-2.26; P for trend = 0.01). The ORs for skin lesions in relation to the methylenetetrahydrofolate reductase 677TT/1298AA and 677CT/1298AA diplotypes (compared with 677CC/1298CC diplotype) were 1.66 (95% CI, 1.00-2.77) and 1.77 (95% CI, 0.61-5.14), respectively. The OR for skin lesions in relation to the glutathione S-transferase omega1 diplotype containing all at-risk alleles was 3.91 (95% CI, 1.03-14.79). Analysis of joint effects of genotypes/diplotypes with water arsenic concentration and urinary %MMA suggests additivity of these factors. The findings suggest that arsenic metabolism, particularly the conversion of MMA to DMA, may be saturable and that differences in urinary arsenic metabolites, genetic factors related to arsenic metabolism, and their joint distributions modulate arsenic toxicity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1270-8
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17548696-Arsenic, pubmed-meshheading:17548696-Arsenic Poisoning, pubmed-meshheading:17548696-Bangladesh, pubmed-meshheading:17548696-Cacodylic Acid, pubmed-meshheading:17548696-Case-Control Studies, pubmed-meshheading:17548696-Female, pubmed-meshheading:17548696-Genetic Predisposition to Disease, pubmed-meshheading:17548696-Glutathione Transferase, pubmed-meshheading:17548696-Humans, pubmed-meshheading:17548696-Male, pubmed-meshheading:17548696-Methylenetetrahydrofolate Dehydrogenase (NADP), pubmed-meshheading:17548696-Organometallic Compounds, pubmed-meshheading:17548696-Polymorphism, Single Nucleotide, pubmed-meshheading:17548696-Precancerous Conditions, pubmed-meshheading:17548696-Skin Diseases, pubmed-meshheading:17548696-Water Pollutants, Chemical, pubmed-meshheading:17548696-Water Pollution, Chemical
pubmed:year
2007
pubmed:articleTitle
Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh.
pubmed:affiliation
Departments of Epidemiology, Columbia University, USA. habib@uchicago.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural