Linked Life Data

17548684

Source:http://linkedlifedata.com/resource/pubmed/id/17548684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-6-5
pubmed:abstractText
Many host factors or biomarkers are involved in the process of early DNA damage induced by occupational exposure to polycyclic aromatic hydrocarbons (PAH) as seen in coke-oven workers. This paper aimed to identify complicated causal interrelationship of various biomarkers using the path analysis. In this analysis, we included 235 subjects (166 coke-oven workers and 69 nonexposed controls) whose data on the comet assay (e.g., Olive tail moment) and cytogenetic analysis of peripheral blood lymphocytes as well as urinary 1-hydroxypyrene (1-OHP) were available. The path analysis showed that coke-oven exposure and tobacco smoke were both significant predictors of the concentrations of urinary 1-OHP (P < 0.05), with a coefficient of determination of 0.75. The factors having significant influence on the Olive tail moment were in the following order: urinary 1-OHP > XRCC1-exon 9 variant genotype > ERCC2-exon 10 variant genotype > XRCC1-exon 6 variant genotype, with a coefficient of determination of 0.22. The variables of relative importance in influencing on cytokinesis-block micronucleus frequencies were in the following order: coke-oven exposure > urinary 1-OHP > age > mEH3 variant genotype > ERCC2-exon 10 variant genotype > XRCC1-exon 6 variant genotype, with a coefficient of determination of 0.27. These results indicated that exogenous agents, especially the coke-oven exposure, played a more important role than the genotypes in the induction of early genetic damage. In conclusion, the path analysis seemed to be an alternative statistical approach for the ascertainment of complicated association among related biomarkers for the assessment of occupational exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1193-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17548684-Adult, pubmed-meshheading:17548684-Age Factors, pubmed-meshheading:17548684-Biological Markers, pubmed-meshheading:17548684-Coke, pubmed-meshheading:17548684-Comet Assay, pubmed-meshheading:17548684-DNA Damage, pubmed-meshheading:17548684-DNA-Binding Proteins, pubmed-meshheading:17548684-Female, pubmed-meshheading:17548684-Genotype, pubmed-meshheading:17548684-Humans, pubmed-meshheading:17548684-Male, pubmed-meshheading:17548684-Middle Aged, pubmed-meshheading:17548684-Occupational Exposure, pubmed-meshheading:17548684-Polycyclic Hydrocarbons, Aromatic, pubmed-meshheading:17548684-Polymerase Chain Reaction, pubmed-meshheading:17548684-Polymorphism, Genetic, pubmed-meshheading:17548684-Pyrenes, pubmed-meshheading:17548684-Smoking, pubmed-meshheading:17548684-Xeroderma Pigmentosum Group D Protein
pubmed:year
2007
pubmed:articleTitle
Path analysis of biomarkers of exposure and early biological effects among coke-oven workers exposed to polycyclic aromatic hydrocarbons.
pubmed:affiliation
Department of Epidemiology and Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't