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rdf:type |
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lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0014834,
umls-concept:C0017337,
umls-concept:C0023122,
umls-concept:C0205221,
umls-concept:C0231202,
umls-concept:C0370215,
umls-concept:C0439831,
umls-concept:C0542329,
umls-concept:C0542559,
umls-concept:C0597979,
umls-concept:C1880371
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-23
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pubmed:databankReference |
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pubmed:abstractText |
A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared to that observed in the same settings in 2002 (1.7% in 2005 versus 0.1% in 2002). In this work, we demonstrated that this phenomenon was mainly related to the dissemination of CTX-M-type extended-spectrum beta-lactamase (ESBL) determinants among commensal E. coli strains. Of 50 ESBL-producing isolates collected in the 2005 survey, 44 harbored a CTX-M-type and 6 an SHV-type (SHV-2 or SHV-12) ESBL. Compared to 2002 results, an increased diversity of CTX-M-type ESBLs was also observed: members of the CTX-M-1 group (CTX-M-15) emerged in Bolivia (where only CTX-M-2 was observed in 2002), while members of the CTX-M-9 group (CTX-M-14 and CTX-M-24) emerged in Peru (where only CTX-M-15 and CTX-M-2 were observed in 2002). A new CTX-M-2 variant named CTX-M-56 was also detected. Molecular characterization of the CTX-M-producing isolates and gene transfer experiments suggested that different mechanisms could be involved in the spreading of different CTX-M group determinants and revealed that additional resistance determinants for non-beta-lactam antibiotics were preferentially carried by plasmids encoding certain CTX-M variants (CTX-M-15 and variants of the CTX-M-2 group). Three CTX-M-15-encoding conjugative plasmids from Peruvian isolates carried the new fluoroquinolone resistance gene aac(6')-Ib-cr. To our best knowledge, this is the first report of the detection of aac(6')-Ib-cr in Latin America.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-11010916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-11574608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-11585791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-11796390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-12760899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-12936986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-1378398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-14693512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-15388431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-15561825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-15673804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-15935499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16223952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16291869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16323089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16369542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16511754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16569837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16672390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16707045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16870791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16940132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16942899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-16954321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-17008172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-17083012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-8834913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17548490-9163473
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2720-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17548490-Anti-Bacterial Agents,
pubmed-meshheading:17548490-Bolivia,
pubmed-meshheading:17548490-Ceftriaxone,
pubmed-meshheading:17548490-Cephalosporin Resistance,
pubmed-meshheading:17548490-Child,
pubmed-meshheading:17548490-Child, Preschool,
pubmed-meshheading:17548490-Conjugation, Genetic,
pubmed-meshheading:17548490-Drug Resistance, Bacterial,
pubmed-meshheading:17548490-Escherichia coli,
pubmed-meshheading:17548490-Feces,
pubmed-meshheading:17548490-Gene Transfer, Horizontal,
pubmed-meshheading:17548490-Genetic Variation,
pubmed-meshheading:17548490-Humans,
pubmed-meshheading:17548490-Infant,
pubmed-meshheading:17548490-Microbial Sensitivity Tests,
pubmed-meshheading:17548490-Molecular Sequence Data,
pubmed-meshheading:17548490-Peru,
pubmed-meshheading:17548490-Plasmids,
pubmed-meshheading:17548490-Poverty,
pubmed-meshheading:17548490-Sequence Analysis, DNA,
pubmed-meshheading:17548490-Time Factors,
pubmed-meshheading:17548490-beta-Lactamases
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pubmed:year |
2007
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pubmed:articleTitle |
Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America.
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pubmed:affiliation |
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Policlinico Santa Maria alle Scotte, Siena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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