Linked Life Data

17544673

Source:http://linkedlifedata.com/resource/pubmed/id/17544673

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2007-6-26
pubmed:abstractText
As part of our search for potential anticonvulsant agents, a set of compounds were designed, synthesized, and evaluated against MES and PTZ tests. Bioisosteric functional group information was used to design a new functionality, sulfamides, that complies with the requirements of the pharmacophore previously defined. Some of the molecules showed a promising anticonvulsant profile as selective anti-MES drugs, being active at low concentrations (30mg/kg). The biological data were confirmed in Phase II of the Anticonvulsant Drug Development Program of the National Institute of Health.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5604-14
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Design, synthesis, and anticonvulsant activity of some sulfamides.
pubmed:affiliation
Medicinal Chemistry, Department of Biological Sciences, National University of La Plata, 47 and 115, La Plata B1900BJW, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't