Linked Life Data

17541984

Source:http://linkedlifedata.com/resource/pubmed/id/17541984

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Following our report of a linkage at 12q24 with a phenotype of obesity under antipsychotics, we tested the pro-melanin-concentrating hormone (PMCH) candidate gene for a possible association in humans with the body mass index (BMI; kg/m2) in unrelated schizophrenic patients (SZ) receiving antipsychotics (N = 300) and in controls (CTL; N = 150). Subjects were classified in obese (OB) (BMI > or = 30 kg/m2), overweight (25 < or = BMI < 30 kg/m2), and normal weight (BMI < 25 kg/m2) groups. Single nucleotide polymorphisms (SNP) rs7973796 and rs11111201, located 5' at -4.5 kb and 3' at +1.8 kb, respectively, of PMCH were genotyped. Interaction effects of genotypes and antipsychotic treatment on BMI were tested in a covariance analysis with age and gender as covariates. Interaction effects on the prevalence of obesity were tested in a logistic regression analysis. For subjects under 50 years, the effect of the rs7973796 genotype on BMI differed between the SZ patients taking olanzapine and CTL group (interaction P = 0.025). Olanzapine-treated SZ patients carrying the ancestral homozygote genotype showed a higher BMI for rs7973796 (P = 0.016 with the LSMeans t-test) than the variant homozygotes. Accordingly, the ORs for obesity associated with rs7973796 genotypes differed in the SZ patients taking olanzapine compared to the CTL group (interaction P = 0.0094). The G allele was associated with an increase in the odds of obesity in SZ patients taking olanzapine. No association was observed for those over 50 years, or for rs11111201. These results suggest that the common allele of PMCH rs7973796 may be associated with a greater BMI in olanzapine-treated SZ patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1552-485X
pubmed:author
pubmed:copyrightInfo
2007 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
144B
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1063-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17541984-Adult, pubmed-meshheading:17541984-Age Distribution, pubmed-meshheading:17541984-Aged, pubmed-meshheading:17541984-Antipsychotic Agents, pubmed-meshheading:17541984-Benzodiazepines, pubmed-meshheading:17541984-Body Mass Index, pubmed-meshheading:17541984-Case-Control Studies, pubmed-meshheading:17541984-Female, pubmed-meshheading:17541984-Genetic Linkage, pubmed-meshheading:17541984-Genetic Predisposition to Disease, pubmed-meshheading:17541984-Genotype, pubmed-meshheading:17541984-Homozygote, pubmed-meshheading:17541984-Humans, pubmed-meshheading:17541984-Hypothalamic Hormones, pubmed-meshheading:17541984-Male, pubmed-meshheading:17541984-Middle Aged, pubmed-meshheading:17541984-Obesity, pubmed-meshheading:17541984-Polymorphism, Single Nucleotide, pubmed-meshheading:17541984-Protein Precursors, pubmed-meshheading:17541984-Psychotic Disorders, pubmed-meshheading:17541984-Schizophrenia, pubmed-meshheading:17541984-Sex Distribution, pubmed-meshheading:17541984-Weight Gain
pubmed:year
2007
pubmed:articleTitle
Possible association of the pro-melanin-concentrating hormone gene with a greater body mass index as a side effect of the antipsychotic olanzapine.
pubmed:affiliation
Laval University Robert-Giffard Research Center, Québec, Canada. Yvon.Chagnon@crulrg.ulaval.ca
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't