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rdf:type |
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lifeskim:mentions |
umls-concept:C0028125,
umls-concept:C0205314,
umls-concept:C0538674,
umls-concept:C0679622,
umls-concept:C0747055,
umls-concept:C0871261,
umls-concept:C1527148,
umls-concept:C1554080,
umls-concept:C1704410,
umls-concept:C1704632,
umls-concept:C1706198,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-19
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pubmed:abstractText |
Nitrate tolerance is likely attributable to an increased production of reactive oxygen species (ROS) leading to an inhibition of the mitochondrial aldehyde dehydrogenase (ALDH-2), representing the nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN) bioactivating enzyme, and to impaired nitric oxide bioactivity and signaling. We tested whether differences in their capacity to induce heme oxygenase-1 (HO-1) might explain why PETN and not GTN therapy is devoid of nitrate and cross-tolerance.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:ColdeweyMeikeM,
pubmed-author:DaiberAndreasA,
pubmed-author:FörstermannUlrichU,
pubmed-author:HinkUlrichU,
pubmed-author:HortmannMarcusM,
pubmed-author:HsiaoH CHC,
pubmed-author:LehmannJochenJ,
pubmed-author:MünzelThomasT,
pubmed-author:MollnauHankeH,
pubmed-author:OelzeMatthiasM,
pubmed-author:SeelingAndreasA,
pubmed-author:StalleickenDirkD,
pubmed-author:WeinerHenryH,
pubmed-author:WenzelPhilipP
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1729-35
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pubmed:meshHeading |
pubmed-meshheading:17541025-Aldehyde Dehydrogenase,
pubmed-meshheading:17541025-Animals,
pubmed-meshheading:17541025-Chromatography, High Pressure Liquid,
pubmed-meshheading:17541025-Cyclic GMP,
pubmed-meshheading:17541025-Disease Models, Animal,
pubmed-meshheading:17541025-Drug Tolerance,
pubmed-meshheading:17541025-Endothelium, Vascular,
pubmed-meshheading:17541025-Free Radical Scavengers,
pubmed-meshheading:17541025-Heme Oxygenase-1,
pubmed-meshheading:17541025-Male,
pubmed-meshheading:17541025-Nitroglycerin,
pubmed-meshheading:17541025-Pentaerythritol Tetranitrate,
pubmed-meshheading:17541025-Probability,
pubmed-meshheading:17541025-Random Allocation,
pubmed-meshheading:17541025-Rats,
pubmed-meshheading:17541025-Rats, Wistar,
pubmed-meshheading:17541025-Reactive Oxygen Species,
pubmed-meshheading:17541025-Reference Values,
pubmed-meshheading:17541025-Sensitivity and Specificity
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pubmed:year |
2007
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pubmed:articleTitle |
Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.
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pubmed:affiliation |
II. Medizinische Klinik, Johannes-Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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