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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0027882,
umls-concept:C0178696,
umls-concept:C0205245,
umls-concept:C0205345,
umls-concept:C0598958,
umls-concept:C1512474,
umls-concept:C1655731,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C2266853,
umls-concept:C2603343
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pubmed:issue |
13
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pubmed:dateCreated |
2007-6-21
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pubmed:abstractText |
We compare the ability of two structurally different classes of epigenetic modulators, namely, histone deacetylase (HDAC) inhibitors containing either a hydroxamate or a mercaptoacetamide as the zinc binding group, to protect cortical neurons in culture from oxidative stress-induced death. This study reveals that some of the mercaptoacetamide-based HDAC inhibitors are fully protective, whereas the hydroxamates show toxicity at higher concentrations. Our present results appear to be consistent with the possibility that the mercaptoacetamide-based HDAC inhibitors interact with a different subset of the HDAC isozymes [less activity at HDAC1 and 2 correlates with less inhibitor toxicity], or alternatively, are interacting selectively with only the cytoplasmic HDACs that are crucial for protection from oxidative stress.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3054-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17539623-Acetamides,
pubmed-meshheading:17539623-Acetylation,
pubmed-meshheading:17539623-Animals,
pubmed-meshheading:17539623-Cell Survival,
pubmed-meshheading:17539623-Cells, Cultured,
pubmed-meshheading:17539623-Cerebral Cortex,
pubmed-meshheading:17539623-Epigenesis, Genetic,
pubmed-meshheading:17539623-Histone Deacetylase Inhibitors,
pubmed-meshheading:17539623-Histone Deacetylases,
pubmed-meshheading:17539623-Histones,
pubmed-meshheading:17539623-Hydroxamic Acids,
pubmed-meshheading:17539623-Isoenzymes,
pubmed-meshheading:17539623-Neurons,
pubmed-meshheading:17539623-Neuroprotective Agents,
pubmed-meshheading:17539623-Oxidative Stress,
pubmed-meshheading:17539623-Rats,
pubmed-meshheading:17539623-Rats, Sprague-Dawley,
pubmed-meshheading:17539623-Structure-Activity Relationship,
pubmed-meshheading:17539623-Sulfhydryl Compounds
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pubmed:year |
2007
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pubmed:articleTitle |
Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.
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pubmed:affiliation |
Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA. kozikowa@uic.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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