Source:http://linkedlifedata.com/resource/pubmed/id/17538871
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2007-7-10
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| pubmed:abstractText |
Two phenylpropanoids, 1-allyl-3,5-dimethoxy-4-(3-methyl-but-2-enyloxy)benzene ( 4) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol ( 6), and two phytoquinoids, 4 R-(-)-illicinone-A ( 7) and 2 S,4 R-(-)-illicinone-B ( 8), isolated from plants of the ILLICIUM species significantly inhibited histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with A23187. Furthermore, these compounds caused a decline in TNF-alpha levels in culture supernatants of RBL-2H3 cells following treatment with A23187. The results indicate that these compounds might be useful as anti-inflammatory agents against mast cell-mediated inflammatory diseases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0032-0943
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
662-5
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| pubmed:meshHeading |
pubmed-meshheading:17538871-Animals,
pubmed-meshheading:17538871-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17538871-Cell Line, Tumor,
pubmed-meshheading:17538871-Dose-Response Relationship, Drug,
pubmed-meshheading:17538871-Histamine Release,
pubmed-meshheading:17538871-Illicium,
pubmed-meshheading:17538871-Mast Cells,
pubmed-meshheading:17538871-Phytotherapy,
pubmed-meshheading:17538871-Plant Extracts,
pubmed-meshheading:17538871-Rats
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Anti-inflammatory activity of phenylpropanoids and phytoquinoids from Illicium species in RBL-2H3 cells.
|
| pubmed:affiliation |
Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya, Aichi, Japan. tmatsui@aichi-med-u.ac.jp
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| pubmed:publicationType |
Journal Article
|