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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2007-7-26
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pubmed:abstractText |
Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537848-10073943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537848-10352317,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17537848-9815238
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:BealDominic RDR,
pubmed-author:BeanAlex TAT,
pubmed-author:BorchardtGretta JGJ,
pubmed-author:CarringtonMaryM,
pubmed-author:GliddenChrystal ECE,
pubmed-author:LifsonJeffrey DJD,
pubmed-author:LoffredoJohn TJT,
pubmed-author:MaxwellJessJ,
pubmed-author:QiYingY,
pubmed-author:RehrauerWilliam MWM,
pubmed-author:SomaTaekoT,
pubmed-author:WatkinsDavid IDI,
pubmed-author:WilsonNancy ANA
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8827-32
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17537848-Alleles,
pubmed-meshheading:17537848-Animals,
pubmed-meshheading:17537848-Base Sequence,
pubmed-meshheading:17537848-Genetic Testing,
pubmed-meshheading:17537848-Histocompatibility Antigens Class I,
pubmed-meshheading:17537848-Macaca mulatta,
pubmed-meshheading:17537848-Molecular Sequence Data,
pubmed-meshheading:17537848-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:17537848-Simian immunodeficiency virus,
pubmed-meshheading:17537848-Viremia,
pubmed-meshheading:17537848-Virus Replication
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pubmed:year |
2007
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pubmed:articleTitle |
Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
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pubmed:affiliation |
Wisconsin National Primate Research Center, University of Wisconsin-Madison, 555 Science Drive, Madison, WI 53711, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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