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rdf:type |
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lifeskim:mentions |
umls-concept:C0007776,
umls-concept:C0009148,
umls-concept:C0019564,
umls-concept:C0027882,
umls-concept:C0034693,
umls-concept:C0146017,
umls-concept:C0205234,
umls-concept:C0205263,
umls-concept:C0439962,
umls-concept:C1280500,
umls-concept:C1883709
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pubmed:issue |
1
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pubmed:dateCreated |
1992-1-29
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pubmed:abstractText |
In the cobalt focus experimental epilepsy model, severe hippocampal neuron damage occurs with marked EEG changes. The effects of TJ-960, a herbal medicine formulation, were studied on neuron damage in the CA1 area of rat hippocampus. Continuous oral administration of TJ-960 from one month prior to the cobalt application showed almost complete protection against hippocampal neuron damage induced by cobalt application to the cerebral cortex. TJ-960 also completely inhibited the EEG changes as well as the brain edema induced by cobalt application.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0378-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1753783-Animals,
pubmed-meshheading:1753783-Anticonvulsants,
pubmed-meshheading:1753783-Body Water,
pubmed-meshheading:1753783-Brain Chemistry,
pubmed-meshheading:1753783-Brain Edema,
pubmed-meshheading:1753783-Cerebral Cortex,
pubmed-meshheading:1753783-Cobalt,
pubmed-meshheading:1753783-Drugs, Chinese Herbal,
pubmed-meshheading:1753783-Electroencephalography,
pubmed-meshheading:1753783-Epilepsy,
pubmed-meshheading:1753783-Hippocampus,
pubmed-meshheading:1753783-Neurons,
pubmed-meshheading:1753783-Pyramidal Tracts,
pubmed-meshheading:1753783-Rats,
pubmed-meshheading:1753783-Rats, Inbred Strains
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pubmed:year |
1991
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pubmed:articleTitle |
Protective effects of TJ-960 herbal mixture on hippocampal neuron damage induced by cobalt focus in the cerebral cortex of rats.
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pubmed:affiliation |
Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
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pubmed:publicationType |
Journal Article
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