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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-6-28
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pubmed:abstractText |
N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens. Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. Inflammatory bowel diseases (IBD) consist of Crohn's disease (CD) and ulcerative colitis (UC), both are associated with increased colorectal cancer (CRC) risk. We hypothesized that NAT1 and/or NAT2 polymorphisms contribute to the increased cancer evident in IBD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-10667461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-10828908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11095339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11141315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11185617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11241255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11247898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11785715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11796261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11814304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-11950911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-12135032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-12165742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-12186410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-12486941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-12955743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-16097053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-16170896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-16550165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-2365498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-2793156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-3293663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-3345932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-3778197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-3815349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-7828978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-8081359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-8200559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17537267-9301503
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2350
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17537267-Adult,
pubmed-meshheading:17537267-Aged,
pubmed-meshheading:17537267-Aged, 80 and over,
pubmed-meshheading:17537267-Arylamine N-Acetyltransferase,
pubmed-meshheading:17537267-Case-Control Studies,
pubmed-meshheading:17537267-Colitis, Ulcerative,
pubmed-meshheading:17537267-Colorectal Neoplasms,
pubmed-meshheading:17537267-Crohn Disease,
pubmed-meshheading:17537267-Female,
pubmed-meshheading:17537267-Gene Frequency,
pubmed-meshheading:17537267-Genetic Predisposition to Disease,
pubmed-meshheading:17537267-Haplotypes,
pubmed-meshheading:17537267-Humans,
pubmed-meshheading:17537267-Isoenzymes,
pubmed-meshheading:17537267-Male,
pubmed-meshheading:17537267-Middle Aged,
pubmed-meshheading:17537267-Polymorphism, Single Nucleotide
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pubmed:year |
2007
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pubmed:articleTitle |
Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma.
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pubmed:affiliation |
Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA. ssmahi01@gwise.louisville.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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