Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-6-12
pubmed:abstractText
Vaccinia virus immunization provides lifelong protection against smallpox, but the mechanisms of this exquisite protection are unknown. We used polychromatic flow cytometry to characterize the functional and phenotypic profile of CD8(+) T cells induced by vaccinia virus immunization in a comparative vaccine trial of modified vaccinia virus Ankara (MVA) versus Dryvax immunization in which protection was assessed against subsequent Dryvax challenge. Vaccinia virus-specific CD8(+) T cells induced by both MVA and Dryvax were highly polyfunctional; they degranulated and produced interferon gamma, interleukin 2, macrophage inflammatory protein 1beta, and tumor necrosis factor alpha after antigenic stimulation. Responding CD8(+) T cells exhibited an unusual phenotype (CD45RO(-)CD27(intermediate)). The unique phenotype and high degree of polyfunctionality induced by vaccinia virus also extended to inserted HIV gene products of recombinant NYVAC. This quality of the CD8(+) T cell response may be at least partially responsible for the profound efficacy of these vaccines in protection against smallpox and serves as a benchmark against which other vaccines can be evaluated.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-10075982, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-10322299, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-10358151, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-10537110, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-10545993, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-10982361, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11014195, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11884484, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11884558, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11914379, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11923489, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11927633, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11937579, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-11983230, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12023339, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12023773, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12414720, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12477501, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12668642, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12766765, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-12925846, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-14580882, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-15014500, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-15184506, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-15286731, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-15346340, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-1566575, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-15872023, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-15951823, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-16172378, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-16287711, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-16339586, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-16467198, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-16756987, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-16862156, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-17126963, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-2033387, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-7612234, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-7876536, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-8057491, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-8207839, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-8642697, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-9018240, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-9018241, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-9050875, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-9348298, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-9400593, http://linkedlifedata.com/resource/pubmed/commentcorrection/17535971-9933172
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1405-16
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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