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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0011854,
umls-concept:C0017262,
umls-concept:C0020885,
umls-concept:C0061355,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0332162,
umls-concept:C0439799,
umls-concept:C0439855,
umls-concept:C1305923,
umls-concept:C2587213,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-30
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pubmed:abstractText |
The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Gastric Inhibitory Polypeptide,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Kir6.2 channel,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Inwardly...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Drug,
http://linkedlifedata.com/resource/pubmed/chemical/sulfonylurea receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0804-4643
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pubmed:author |
pubmed-author:ØrskovCathrineC,
pubmed-author:ChiarelliFrancescoF,
pubmed-author:GammeltoftSteenS,
pubmed-author:HansenLarsL,
pubmed-author:HollReinhardR,
pubmed-author:HolstJens JJJ,
pubmed-author:HougaardPhilipP,
pubmed-author:Hvidøre Study Group,
pubmed-author:Jansen-OlesenIngerI,
pubmed-author:MortensenHenrik BHB,
pubmed-author:NielsenLotte BLB,
pubmed-author:PörksenSvenS,
pubmed-author:PlougKenneth BKB,
pubmed-author:RorsmanPatrikP,
pubmed-author:SwiftPeterP,
pubmed-author:de BeaufortCarineC
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pubmed:issnType |
Print
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-71
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17535866-ATP-Binding Cassette Transporters,
pubmed-meshheading:17535866-Adolescent,
pubmed-meshheading:17535866-Blotting, Western,
pubmed-meshheading:17535866-C-Peptide,
pubmed-meshheading:17535866-Child,
pubmed-meshheading:17535866-Diabetes Mellitus, Type 1,
pubmed-meshheading:17535866-Eating,
pubmed-meshheading:17535866-Female,
pubmed-meshheading:17535866-Gastric Inhibitory Polypeptide,
pubmed-meshheading:17535866-Genotype,
pubmed-meshheading:17535866-Glucagon,
pubmed-meshheading:17535866-Glucagon-Like Peptide 1,
pubmed-meshheading:17535866-Hemoglobin A, Glycosylated,
pubmed-meshheading:17535866-Humans,
pubmed-meshheading:17535866-Hyperglycemia,
pubmed-meshheading:17535866-Hypoglycemic Agents,
pubmed-meshheading:17535866-Ileum,
pubmed-meshheading:17535866-Immunohistochemistry,
pubmed-meshheading:17535866-Insulin,
pubmed-meshheading:17535866-Islets of Langerhans,
pubmed-meshheading:17535866-Male,
pubmed-meshheading:17535866-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:17535866-Potassium Channels,
pubmed-meshheading:17535866-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:17535866-Receptors, Drug
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pubmed:year |
2007
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pubmed:articleTitle |
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
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pubmed:affiliation |
Department of Paediatrics, Glostrup University Hospital, Ndr. Ringvej 57, DK-2600 Glostrup, Denmark. lotbrn01@glo.regionh.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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