Linked Life Data

17534945

Source:http://linkedlifedata.com/resource/pubmed/id/17534945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-9-5
pubmed:abstractText
A semi professional marathon runner at risk for Huntington's disease (HD) (43 CAG repeats) developed signs of a slowly progressive myopathy with exercise-induced muscle fatigue, pain, elevated creatine kinase level, and worsening of his running performance many years before first signs of chorea were detected. Muscle biopsy displayed a mild myopathy with mitochondrial pathology including a complex IV deficiency and analysis of the patient's fibroblast culture demonstrated deficits in mitochondrial function. Challenging skeletal muscle by excessive training might have disclosed myopathy in HD even years before the appearance of other neurological symptoms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0885-3185
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2007 Movement Disorder Society.
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1637-40
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Myopathy as a first symptom of Huntington's disease in a Marathon runner.
pubmed:affiliation
Department of Neurology, University Hospital RWTH Aachen, Germany. ckosinski@ukaachen.de
pubmed:publicationType
Journal Article, Case Reports