Linked Life Data

17534135

Source:http://linkedlifedata.com/resource/pubmed/id/17534135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-8-13
pubmed:abstractText
Stereotactic ventralis intermedius (Vim) thalamotomy is effective for essential tremor (ET) of the limb, but the effect on the activity of the sensorimotor cortex is still unclear. The functional changes in this cortical area of patients with ET after Vim thalamotomy were investigated using functional magnetic resonance (fMR) imaging. Six patients underwent Vim thalamotomy for medically intractable ET, predominantly in the right hand. 1.5-tesla fMR imaging was performed using the blood oxygenation level-dependent sequence, before and after Vim thalamotomy, during passive movements with right wrist flexion and extension. Before and after images were analyzed using SPM99 software. Activation in the sensorimotor cortex and supplementary motor area evoked by wrist passive movement was observed both before and after surgery. Group analysis of changes in the blood oxygenation level-dependent response revealed a significantly smaller activated area postoperatively. Activation at the fundus of the central sulcus was characteristically decreased. All patients showed marked improvement in tremor after Vim thalamotomy. No patient experienced neurological deficits. fMR imaging showed that activation at the fundus of the central sulcus evoked by passive wrist movement was suppressed after Vim thalamotomy in ET patients, probably due to disruption of the thalamocortical pathway. The fundus of the central sulcus (Brodmann area 3a) is likely to be one of the key relays in the tremor circuit.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1011-6125
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2007 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-34
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Effect of ventralis intermedius thalamotomy on the area in the sensorimotor cortex activated by passive hand movements: fMR imaging study.
pubmed:affiliation
Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan. miyagisi@med.gunma-u.ac.jp
pubmed:publicationType
Journal Article, Case Reports