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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
46
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pubmed:dateCreated |
2007-10-11
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pubmed:abstractText |
Protein inhibitor of activated STAT (Pias) and human homologues of seven in absentia (hSiah) proteins both exhibit properties of ubiquitin-family peptides conjugating enzymes. Pias present E3-ligase activity for small ubiquitin-related modifiers (Sumo) covalent attachment to their targets. This post-translational modification is responsible for the activation of different transcription factors such as AP1. HSiah proteins possess ubiquitin-E3-ligase activity that triggers their partners to proteasomal-dependent degradation. The present study identifies Pias as a new hSiah2-interacting protein. We demonstrate that hSiah2 regulates specifically the proteasome-dependent degradation of Pias proteins. On reverse, Pias does not prevent hSiah2 degradation. We provide evidences for hSiah2-dependent degradation of Pias as being a mechanism in the regulation of c-jun N-terminal kinase-activating pathways. This report describes a new interconnection between sumoylation and ubiquitination pathways by regulating the levels of the E3-ligases available for these processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6665-76
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17533377-Cell Line,
pubmed-meshheading:17533377-Cell Nucleus,
pubmed-meshheading:17533377-Gene Expression Regulation,
pubmed-meshheading:17533377-Humans,
pubmed-meshheading:17533377-MAP Kinase Kinase 4,
pubmed-meshheading:17533377-Nuclear Proteins,
pubmed-meshheading:17533377-Proteasome Endopeptidase Complex,
pubmed-meshheading:17533377-Protein Inhibitors of Activated STAT,
pubmed-meshheading:17533377-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:17533377-SUMO-1 Protein,
pubmed-meshheading:17533377-Transcriptional Activation,
pubmed-meshheading:17533377-Ubiquitin-Protein Ligases,
pubmed-meshheading:17533377-Ubiquitination
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pubmed:year |
2007
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pubmed:articleTitle |
A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.
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pubmed:affiliation |
Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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