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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
15
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pubmed:dateCreated |
2007-7-10
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pubmed:abstractText |
Aiming to develop selective anticancer drugs, we designed and synthesized three disulfides bearing a folic acid moiety as candidate folate receptor (FR)-targeted prodrugs of thiolate histone deacetylase inhibitors. Among them, compound 1 displayed growth-inhibitory activity toward folate receptor-positive MCF-7 breast cancer cells. The activity of 1 was significantly reduced by free folic acid, suggesting that cellular uptake of 1 is mediated by FR.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4208-12
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17532630-Carrier Proteins,
pubmed-meshheading:17532630-Cell Line, Tumor,
pubmed-meshheading:17532630-Drug Design,
pubmed-meshheading:17532630-Enzyme Inhibitors,
pubmed-meshheading:17532630-Folate Receptors, GPI-Anchored,
pubmed-meshheading:17532630-Histone Deacetylase Inhibitors,
pubmed-meshheading:17532630-Humans,
pubmed-meshheading:17532630-Prodrugs,
pubmed-meshheading:17532630-Receptors, Cell Surface,
pubmed-meshheading:17532630-Sulfhydryl Compounds
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.
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|
pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. suzuki@phar.nagoya-cu.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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