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pubmed-article:17532074pubmed:abstractTextHypoxia is a common feature of solid tumors associated with therapy resistance, increased malignancy and poor prognosis. Several approaches have been developed with the hope of identifying patients harboring hypoxic tumors including the use of microarray based gene signatures. However, studies to date have largely ignored the strong time dependency of hypoxia-regulated gene expression. We hypothesized that use of time-dependent patterns of gene expression during hypoxia would enable development of superior prognostic expression signatures.lld:pubmed
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pubmed-article:17532074pubmed:articleTitleImpact of supervised gene signatures of early hypoxia on patient survival.lld:pubmed
pubmed-article:17532074pubmed:affiliationMaastricht Radiation Oncology (Maastro), GROW Research Institute, Maastricht University, The Netherlands.lld:pubmed
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