|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2007-6-20
|
|
pubmed:abstractText |
Hypoxia is a common feature of solid tumors associated with therapy resistance, increased malignancy and poor prognosis. Several approaches have been developed with the hope of identifying patients harboring hypoxic tumors including the use of microarray based gene signatures. However, studies to date have largely ignored the strong time dependency of hypoxia-regulated gene expression. We hypothesized that use of time-dependent patterns of gene expression during hypoxia would enable development of superior prognostic expression signatures.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0167-8140
|
|
pubmed:author |
pubmed-author:BeggAdrian CAC,
pubmed-author:EveloChris T ACT,
pubmed-author:FungGlennG,
pubmed-author:LambinPhilippeP,
pubmed-author:MagagninMichael GMG,
pubmed-author:McLaughlinG SGS,
pubmed-author:NuytenDimitry S ADS,
pubmed-author:RaoR BharatRB,
pubmed-author:RouschopKasper MKM,
pubmed-author:SeigneuricRenaudR,
pubmed-author:SriramKrishnanK,
pubmed-author:StarmansMaud H WMH,
pubmed-author:WoutersBradly GBG,
pubmed-author:van ErkArieA
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
83
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
374-82
|
|
pubmed:meshHeading |
pubmed-meshheading:17532074-Cell Hypoxia,
pubmed-meshheading:17532074-Databases, Genetic,
pubmed-meshheading:17532074-Epithelial Cells,
pubmed-meshheading:17532074-Female,
pubmed-meshheading:17532074-Gene Expression Profiling,
pubmed-meshheading:17532074-Humans,
pubmed-meshheading:17532074-Hypoxia-Inducible Factor 1,
pubmed-meshheading:17532074-Middle Aged,
pubmed-meshheading:17532074-Neoplasms,
pubmed-meshheading:17532074-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17532074-Oxygen,
pubmed-meshheading:17532074-Predictive Value of Tests,
pubmed-meshheading:17532074-Prognosis,
pubmed-meshheading:17532074-Survival Analysis,
pubmed-meshheading:17532074-Time Factors
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Impact of supervised gene signatures of early hypoxia on patient survival.
|
|
pubmed:affiliation |
Maastricht Radiation Oncology (Maastro), GROW Research Institute, Maastricht University, The Netherlands.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
