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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-11
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pubmed:abstractText |
Patients with a missense mutation of the calsequestrin 2 gene (CASQ2) are at risk for catecholaminergic polymorphic ventricular tachycardia. This mutation (CASQ2(D307H)) results in decreased ability of CASQ2 to bind Ca2+ in the sarcoplasmic reticulum (SR). In this theoretical study, we investigate a potential mechanism by which CASQ2(D307H) manifests its pro-arrhythmic consequences in patients.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-10488061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-10532948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-10533588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-10777735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-11397782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-11704930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-11723027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-12068037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-12456818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-12824441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-14715535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-15050380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-15192026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-15322274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-15485681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-16129795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-16484299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-16601229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-1689051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-17158566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-17524377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-2165130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-2427730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-7506067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17531962-7514509
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-88
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pubmed:dateRevised |
2011-1-10
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pubmed:meshHeading |
pubmed-meshheading:17531962-Action Potentials,
pubmed-meshheading:17531962-Adrenergic beta-Agonists,
pubmed-meshheading:17531962-Animals,
pubmed-meshheading:17531962-Calcium,
pubmed-meshheading:17531962-Calcium Channels, L-Type,
pubmed-meshheading:17531962-Calsequestrin,
pubmed-meshheading:17531962-Death, Sudden, Cardiac,
pubmed-meshheading:17531962-Guinea Pigs,
pubmed-meshheading:17531962-Humans,
pubmed-meshheading:17531962-Ion Channel Gating,
pubmed-meshheading:17531962-Isoproterenol,
pubmed-meshheading:17531962-Models, Animal,
pubmed-meshheading:17531962-Mutation, Missense,
pubmed-meshheading:17531962-Myocardial Contraction,
pubmed-meshheading:17531962-Myocytes, Cardiac,
pubmed-meshheading:17531962-Sarcoplasmic Reticulum,
pubmed-meshheading:17531962-Tachycardia, Ventricular
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pubmed:year |
2007
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pubmed:articleTitle |
Calsequestrin mutation and catecholaminergic polymorphic ventricular tachycardia: a simulation study of cellular mechanism.
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pubmed:affiliation |
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106-7207, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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