Source:http://linkedlifedata.com/resource/pubmed/id/17530176
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2007-10-22
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| pubmed:abstractText |
Chalcones are considered the precursors of flavonoids and have been identified as interesting compounds with antitumor properties. Boronic-chalcone derivatives are more toxic to breast cancer cells compared to normal breast cells. Here, we studied the antitumor activities of trans-4-lodo,4'-boranyl-chalcone (TLBC), which is a boronic-chalcone derivative, in several glioma cell lines. TLBC showed a dose-dependent inhibition with inhibitory concentration 50% value in the muM range (5.5-25.5 microM) in various glioma cell lines. Flow cytometric and western blot assay demonstrated that TLBC induced apoptosis independent of changes to the tumor suppressor p53. This cytotoxic effect was the caspase-dependent manner. Also, TLBC lowered levels of anti-apoptotic Bcl-2 and/or Bcl-X(L) protein in several of the cell lines. To examine the antitumor effect of TLBC in vivo, we used a malignant glioma xenograft model. This result showed that in the mice treated with TLBC at 20 mg/kg, mean tumor volume was reduced by 43.9% (P < 0.01) in comparison with the control group. Immunohistochemical and western blot analysis showed that Bcl-2 protein levels were decreased and Bax protein levels were slightly increased in the tumors injected with 20 mg/kg TLBC compared with the control tumors. Therefore, we conclude that TLBC may be a potential chemotherapeutic agent for human glioma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Boron Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Chalcones,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0167-594X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
85
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
123-32
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| pubmed:meshHeading |
pubmed-meshheading:17530176-Animals,
pubmed-meshheading:17530176-Antineoplastic Agents,
pubmed-meshheading:17530176-Apoptosis,
pubmed-meshheading:17530176-Boron Compounds,
pubmed-meshheading:17530176-Brain Neoplasms,
pubmed-meshheading:17530176-Caspases,
pubmed-meshheading:17530176-Cell Cycle,
pubmed-meshheading:17530176-Cell Line, Tumor,
pubmed-meshheading:17530176-Chalcones,
pubmed-meshheading:17530176-Dose-Response Relationship, Drug,
pubmed-meshheading:17530176-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17530176-Glioma,
pubmed-meshheading:17530176-Humans,
pubmed-meshheading:17530176-Inhibitory Concentration 50,
pubmed-meshheading:17530176-Mice,
pubmed-meshheading:17530176-Mice, Nude,
pubmed-meshheading:17530176-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:17530176-Statistics, Nonparametric,
pubmed-meshheading:17530176-Tumor Suppressor Protein p53,
pubmed-meshheading:17530176-Xenograft Model Antitumor Assays,
pubmed-meshheading:17530176-bcl-2-Associated X Protein
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| pubmed:year |
2007
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| pubmed:articleTitle |
Trans-4-lodo,4'-boranyl-chalcone induces antitumor activity against malignant glioma cell lines in vitro and in vivo.
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| pubmed:affiliation |
Department of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. takasasa@med.kobe-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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