Source:http://linkedlifedata.com/resource/pubmed/id/17530000
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-7-19
|
| pubmed:abstractText |
The role of high-dose therapy and autologous stem cell transplantation (ASCT) for patients with peripheral T-cell lymphoma (PTCL) is poorly defined. Comparisons of outcomes between PTCL and B-cell non-Hodgkin's lymphoma (NHL) have yielded conflicting results, in part due to the rarity and heterogeneity of PTCL. Some retrospective studies have found comparable survival rates for patients with T- and B-cell NHL. In this study, we report our single-center experience of ASCT over one decade using a uniform chemotherapy-only high-dose regimen. Thirty-two patients with PTCL-unspecified (PTCL-u; 11 patients) and anaplastic large-cell lymphoma (21 patients) underwent autologous stem cell transplant, mostly for relapsed or refractory disease. The preparative regimen consisted of busulfan, etoposide and cyclophosphamide. Kaplan-Meier 5-year overall survival (OS) and relapse-free survival (RFS) are 34 and 18%, respectively. These results suggest a poor outcome for patients with PTCL after ASCT, and new therapies for T-cell lymphoma are needed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
239-43
|
| pubmed:meshHeading |
pubmed-meshheading:17530000-Adolescent,
pubmed-meshheading:17530000-Adult,
pubmed-meshheading:17530000-Aged,
pubmed-meshheading:17530000-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17530000-Busulfan,
pubmed-meshheading:17530000-Cyclophosphamide,
pubmed-meshheading:17530000-Disease-Free Survival,
pubmed-meshheading:17530000-Etoposide,
pubmed-meshheading:17530000-Female,
pubmed-meshheading:17530000-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17530000-Humans,
pubmed-meshheading:17530000-Lymphoma, B-Cell,
pubmed-meshheading:17530000-Lymphoma, T-Cell,
pubmed-meshheading:17530000-Male,
pubmed-meshheading:17530000-Middle Aged,
pubmed-meshheading:17530000-Retrospective Studies,
pubmed-meshheading:17530000-Survival Rate,
pubmed-meshheading:17530000-Transplantation, Autologous,
pubmed-meshheading:17530000-Transplantation Conditioning
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen.
|
| pubmed:affiliation |
Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Taussig Cancer Center, Cleveland, OH 44195, USA. smiths11@ccf.org
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|