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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-30
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pubmed:abstractText |
Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P = 2.9 x 10(-4)) and Wegener's granulomatosis in two independent cohorts from the UK (P = 3 x 10(-3)) and France (P = 1.1 x 10(-4)). We did not observe this association in the organ-specific Graves' disease or Addison's disease. Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-10685069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-11315912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-11420040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-11818139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-15273396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-15286789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-15637236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-15742153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-15895083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-16413920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-16482158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-16941003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-1694867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-17122850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17529978-7662988
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:AitmanTimothy JTJ,
pubmed-author:BlakemoreAlexandra I FAI,
pubmed-author:CookH TerenceHT,
pubmed-author:DongRongR,
pubmed-author:FanciulliManuelaM,
pubmed-author:FroguelPhilippeP,
pubmed-author:GoughStephen C LSC,
pubmed-author:GrahamDeborah S CunninghameDS,
pubmed-author:GuillevinLoicL,
pubmed-author:HarperLorraineL,
pubmed-author:HewardJoanne MJM,
pubmed-author:KameshLavanyaL,
pubmed-author:NorsworthyPenny JPJ,
pubmed-author:OwenCatherine JCJ,
pubmed-author:PearceSimon H SSH,
pubmed-author:PetrettoEnricoE,
pubmed-author:PuseyCharles DCD,
pubmed-author:TeixeiraLuisL,
pubmed-author:VyseTimothy JTJ,
pubmed-author:de SmithAdamA
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-3
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17529978-Antigens, CD,
pubmed-meshheading:17529978-Autoimmune Diseases,
pubmed-meshheading:17529978-Autoimmunity,
pubmed-meshheading:17529978-Disease Susceptibility,
pubmed-meshheading:17529978-France,
pubmed-meshheading:17529978-GPI-Linked Proteins,
pubmed-meshheading:17529978-Gene Dosage,
pubmed-meshheading:17529978-Genetic Predisposition to Disease,
pubmed-meshheading:17529978-Genotype,
pubmed-meshheading:17529978-Great Britain,
pubmed-meshheading:17529978-Humans,
pubmed-meshheading:17529978-Lupus Erythematosus, Systemic,
pubmed-meshheading:17529978-Receptors, IgG,
pubmed-meshheading:17529978-Wegener Granulomatosis
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pubmed:year |
2007
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pubmed:articleTitle |
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.
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pubmed:affiliation |
Physiological Genomics and Medicine Group, UK Medical Research Council (MRC) Clinical Sciences Centre, Imperial College, London W12 0NN, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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