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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1992-1-24
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pubmed:abstractText |
The effects of estrogens and tamoxifen were analyzed on estrogen receptor-positive human breast cancer (MCF-7) transplanted into athymic nude mice. It was found that (1) the tumor growth and the proportion of 3H-thymidine-labeled cells were significantly increased in the 17 beta-estradiol dipropionate (E2) group, but significantly decreased in the tamoxifen (TAM) group with respect to the control group, and (2) the tumor content of insulin-like growth factor-1 (IGF-1) and the rate of IGF-1-positive cells were significantly lower in the E2 group, but significantly higher in the TAM group than in the control group. It was concluded that the tumor content of IGF-1 and the proportion of IGF-I-positive cells were inversely correlated to the tumor growth and the 3H-thymidine labeling index in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0910-5050
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1199-202
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1752778-Animals,
pubmed-meshheading:1752778-Breast Neoplasms,
pubmed-meshheading:1752778-Cell Cycle,
pubmed-meshheading:1752778-Cell Division,
pubmed-meshheading:1752778-Cell Line,
pubmed-meshheading:1752778-DNA Replication,
pubmed-meshheading:1752778-Estradiol,
pubmed-meshheading:1752778-Female,
pubmed-meshheading:1752778-Humans,
pubmed-meshheading:1752778-Insulin-Like Growth Factor I,
pubmed-meshheading:1752778-Kinetics,
pubmed-meshheading:1752778-Mice,
pubmed-meshheading:1752778-Mice, Nude,
pubmed-meshheading:1752778-Neoplasm Transplantation,
pubmed-meshheading:1752778-Receptors, Estrogen,
pubmed-meshheading:1752778-Tamoxifen,
pubmed-meshheading:1752778-Transplantation, Heterologous
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pubmed:year |
1991
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pubmed:articleTitle |
Effects of hormones on tumor growth and immunoreactive insulin-like growth factor-1 of estrogen receptor-positive human breast cancer (MCF-7) transplanted in nude mice.
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pubmed:affiliation |
Operation Center, Kanazawa University Hospital.
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pubmed:publicationType |
Journal Article
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