Source:http://linkedlifedata.com/resource/pubmed/id/17526950
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2007-5-28
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| pubmed:abstractText |
The present study was designed to determine whether an association exists between HPA activity and cytokine production in major depression (MD). In 9 patients with MD and 11 control subjects of both sexes, all drug-free, activity of the HPA axis was evaluated by circadian rhythm of plasma cortisol, 24-h free urinary cortisol, an overnight 1 mg dexamethasone suppression test, and an oCRF stimulation test. Spontaneous and LPS-stimulated production of IL-1beta, IL-6, and TNFalpha by peripheral blood mononuclear cells were also determined. We found a significantly elevated spontaneous production of IL-6 in patients with MD (3541.2 +/- 726.8 vs 380.4 +/- 77.5 pg/mL in controls, p < 0.05), while LPS-stimulated production was significantly lower in patients than in control subjects (19,867.7 +/- 3649.2 vs 33,142.2 +/- 15,47.2 pg/mL, p < 0.05). The adrenocorticotropic hormone response to oCRF, evaluated as the area under the curve (AUCACTH) was significantly lower in patients than in control subjects (p = 0.02). A positive correlation between AUCACTH and LPS-stimulated IL-6 secretion was observed in patients with MD (r = 0.75, p < 0.05) but not in controls. These findings suggest that the activation of the inflammatory response described in depression might be associated with long-term hyperactivity of the HPA axis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1355-008X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
371-6
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| pubmed:dateRevised |
2010-6-24
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| pubmed:meshHeading |
pubmed-meshheading:17526950-Adult,
pubmed-meshheading:17526950-Case-Control Studies,
pubmed-meshheading:17526950-Depressive Disorder, Major,
pubmed-meshheading:17526950-Female,
pubmed-meshheading:17526950-Humans,
pubmed-meshheading:17526950-Hypothalamo-Hypophyseal System,
pubmed-meshheading:17526950-Interleukin-6,
pubmed-meshheading:17526950-Leukocytes, Mononuclear,
pubmed-meshheading:17526950-Male,
pubmed-meshheading:17526950-Middle Aged,
pubmed-meshheading:17526950-Pituitary-Adrenal System
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Interleukin-6 production and deregulation of the hypothalamic-pituitary-adrenal axis in patients with major depressive disorders.
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| pubmed:affiliation |
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.
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| pubmed:publicationType |
Journal Article
|