Linked Life Data

17526794

Source:http://linkedlifedata.com/resource/pubmed/id/17526794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2007-7-12
pubmed:abstractText
Acute enteric infections caused by salmonellas remain a major public health burden worldwide. Poultry, particularly chickens, are known to be the main reservoir for this zoonotic pathogen. Although some progress has been made in reducing Salmonella colonization of broiler chickens by using biosecurity and antimicrobials, it still remains a considerable problem. The use of host-specific bacteriophages as a biocontrol is one possible intervention by which Salmonella colonization could be reduced. A total of 232 Salmonella bacteriophages were isolated from poultry farms, abattoirs, and wastewater in 2004 and 2005. Three phages exhibiting the broadest host ranges against Salmonella enterica serotypes Enteritidis, Hadar, and Typhimurium were characterized further by determining their morphology and lytic activity in vitro. These phages were then administered in antacid suspension to birds experimentally colonized with specific Salmonella host strains. The first phage reduced S. enterica serotype Enteritidis cecal colonization by > or = 4.2 log10 CFU within 24 h compared with controls. Administration of the second phage reduced S. enterica serotype Typhimurium by > or = 2.19 log10 CFU within 24 h. The third bacteriophage was ineffective at reducing S. enterica serotype Hadar colonization. Bacteriophage resistance occurred at a frequency commensurate with the titer of phage being administered, with larger phage titers resulting in a greater proportion of resistant salmonellas. The selection of appropriate bacteriophages and optimization of both the timing and method of phage delivery are key factors in the successful phage-mediated control of salmonellas in broiler chickens.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-11162051, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-11181338, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-11544363, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-12142423, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-14532096, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-14969703, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-15240258, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-15580689, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-15726992, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-15746327, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-15844822, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-15895751, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-16269681, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-3156556, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-4019737, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-6355391, http://linkedlifedata.com/resource/pubmed/commentcorrection/17526794-9605979
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0099-2240
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4543-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Bacteriophage therapy to reduce salmonella colonization of broiler chickens.
pubmed:affiliation
Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, United Kingdom. Robert.Atterbury@bristol.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't