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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-25
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pubmed:abstractText |
TGFbeta is a potent candidate for epithelial-mesenchymal transition (EMT) during the development of anterior polar cataracts in the human lens. The Snail superfamily is involved in EMT through the repression of E-cadherin production. This study was conducted to determine whether the Snail gene family is activated in the process of TGFbeta1-induced EMT and how TGFbeta1 regulates the expression of this gene family.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2708-18
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17525203-Animals,
pubmed-meshheading:17525203-Blotting, Western,
pubmed-meshheading:17525203-Cadherins,
pubmed-meshheading:17525203-Cataract,
pubmed-meshheading:17525203-Cell Line,
pubmed-meshheading:17525203-Epithelial Cells,
pubmed-meshheading:17525203-Extracellular Matrix Proteins,
pubmed-meshheading:17525203-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:17525203-Gene Expression Regulation,
pubmed-meshheading:17525203-Gene Silencing,
pubmed-meshheading:17525203-Humans,
pubmed-meshheading:17525203-Lens, Crystalline,
pubmed-meshheading:17525203-Mitogen-Activated Protein Kinases,
pubmed-meshheading:17525203-Phosphorylation,
pubmed-meshheading:17525203-RNA, Messenger,
pubmed-meshheading:17525203-Rats,
pubmed-meshheading:17525203-Rats, Sprague-Dawley,
pubmed-meshheading:17525203-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17525203-Sp1 Transcription Factor,
pubmed-meshheading:17525203-Transcription Factors,
pubmed-meshheading:17525203-Transfection,
pubmed-meshheading:17525203-Transforming Growth Factor beta
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pubmed:year |
2007
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pubmed:articleTitle |
Transforming growth factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells.
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pubmed:affiliation |
Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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