Linked Life Data

17524360

Source:http://linkedlifedata.com/resource/pubmed/id/17524360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-6-4
pubmed:abstractText
Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running intensities. The mRNA for c-fos, a marker for neuronal activation, was up-regulated even under low-intensity running (15 m/min), although its induction appeared to be intensity dependent. On the other hand, increases in BDNF mRNA and protein were seen only at low-intensity running. At moderate-intensity running (25 m/min) which elevated blood lactate and corticosterone levels, induction of BDNF mRNA, but not its protein, was even depressed. Our study shows the first evidence that with an acute low-intensity exercise that is minimally stressful, hippocampal activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield to greater benefits in hippocampal functions compared to the more strenuous forms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
358
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
961-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
BDNF induction with mild exercise in the rat hippocampus.
pubmed:affiliation
Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, 1-1-1 Tennoudai, Tsukuba 305-8574, Japan. hsoya@taiiku.tsukuba.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't