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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-25
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pubmed:abstractText |
The induction of GRIM-19 has been shown to be essential for interferon-beta (IFN-beta)-induced and retinoic acid (RA)-induced tumor cell death. We have studied the localization and levels of GRIM-19 in IFN/RA-induced cell death in neural cells and in focal cerebral ischemia. Exposure to IFN/RA caused a approximately 15-fold increase in GRIM-19 protein levels and induced >50% cell death in human neuroblastoma SH-SY5Y cells. In rats subjected to permanent focal cerebral ischemia, increased oxidative stress, as well as increased GRIM mRNA levels (32-fold) and increased GRIM-19 (>50%) protein levels were noted in the ipsilateral (affected) hemisphere compared with the contralateral (unaffected) hemisphere. These results suggest that GRIM-19 may play a role in ischemia-induced neuronal cell death.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-10924506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-11522775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-12163600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-12472884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-12628925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-12867595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15009667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15261481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15334596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15341512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15367666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15807660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15841082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15857388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-15900303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-16253339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-16826196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-2567130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-3715945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-4572654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-6989691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-7831583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17523870-9059994
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17523870-Animals,
pubmed-meshheading:17523870-Apoptosis,
pubmed-meshheading:17523870-Apoptosis Regulatory Proteins,
pubmed-meshheading:17523870-Brain Ischemia,
pubmed-meshheading:17523870-Cell Line, Tumor,
pubmed-meshheading:17523870-Drug Combinations,
pubmed-meshheading:17523870-Gene Expression Regulation,
pubmed-meshheading:17523870-Humans,
pubmed-meshheading:17523870-Interferon-beta,
pubmed-meshheading:17523870-Male,
pubmed-meshheading:17523870-NADH, NADPH Oxidoreductases,
pubmed-meshheading:17523870-Neuroblastoma,
pubmed-meshheading:17523870-Rats,
pubmed-meshheading:17523870-Rats, Wistar,
pubmed-meshheading:17523870-Time Factors,
pubmed-meshheading:17523870-Tretinoin
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pubmed:year |
2007
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pubmed:articleTitle |
The IFN-beta and retinoic acid-induced cell death regulator GRIM-19 is upregulated during focal cerebral ischemia.
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pubmed:affiliation |
Department of Anesthesiology, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA. zmehr001@umaryland.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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