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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-5-25
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pubmed:abstractText |
It was found that pretreatment of rats with selective agonist of kappa1-opioid receptors (OR) (-)--U--50.488 decreased the incidence of ischemic (10 min) and reperfusion (10 min) ventricular arrhythmias. The selective kappa2-OR agonist GR-89696 had no effect on the incidence of ventricular arrhythmias during a 10-min coronary artery occlusion and following reperfusion in anesthetized rats. The effect of (-)--U-50.488 was abolished by the selective kappa1-OR antagonist of non-binaltorphimine and the non-selective peripheral OR antagonist naloxone methiodide. Perfusion of isolated rat heart with (-)--U-50.488 did not affect arrhythmias during ischemia and reperfusion. The authors suggest that stimulation of kappa1-opioid receptors located outside the central nervous system increases heart resistance against arrhythmogenic action of ischemia/reperfusion, antiarrhythmic action of (-)--U-50.488 being mediated through extracardiac opioid receptors.
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pubmed:language |
rus
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,4-Dichloro-N-methyl-N-(2-(1-pyrrol...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Arrhythmia Agents,
http://linkedlifedata.com/resource/pubmed/chemical/GR 89696,
http://linkedlifedata.com/resource/pubmed/chemical/N-methylnaloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Naltrexone,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quaternary Ammonium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa,
http://linkedlifedata.com/resource/pubmed/chemical/kappa(1) opioid receptor,
http://linkedlifedata.com/resource/pubmed/chemical/kappa(2) opioid receptor,
http://linkedlifedata.com/resource/pubmed/chemical/norbinaltorphimine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0869-8139
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1419-28
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17523463-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-ben...,
pubmed-meshheading:17523463-Animals,
pubmed-meshheading:17523463-Anti-Arrhythmia Agents,
pubmed-meshheading:17523463-Arrhythmias, Cardiac,
pubmed-meshheading:17523463-Myocardial Reperfusion Injury,
pubmed-meshheading:17523463-Myocardium,
pubmed-meshheading:17523463-Naloxone,
pubmed-meshheading:17523463-Naltrexone,
pubmed-meshheading:17523463-Piperazines,
pubmed-meshheading:17523463-Pyrrolidines,
pubmed-meshheading:17523463-Quaternary Ammonium Compounds,
pubmed-meshheading:17523463-Rats,
pubmed-meshheading:17523463-Rats, Wistar,
pubmed-meshheading:17523463-Receptors, Opioid, kappa
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pubmed:year |
2006
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pubmed:articleTitle |
[Role of kappa-opioid receptors in the regulation of cardiac resistance to arrhythmogenic effects of ischemia and reperfusion].
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pubmed:publicationType |
Journal Article,
English Abstract
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