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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2007-7-12
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pubmed:abstractText |
It has long been appreciated that CD4+ T lymphocytes are dysfunctional in human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV)-infected individuals, and it has recently been shown that HIV/SIV infections are associated with a dramatic early destruction of memory CD4+ T lymphocytes. However, the relative contributions of CD4+ T-lymphocyte dysfunction and loss to immune dysregulation during primary HIV/SIV infection have not been fully elucidated. In the current study, we evaluated CD4+ T lymphocytes and their functional repertoire during primary SIVmac251 infection in rhesus monkeys. We show that the extent of loss of memory CD4+ T lymphocytes and staphylococcal enterotoxin B-stimulated cytokine production by total CD4+ T lymphocytes during primary SIVmac251 infection is tightly linked in a cohort of six rhesus monkeys to set point plasma viral RNA levels, with greater loss and dysfunction being associated with higher steady-state viral replication. Moreover, in exploring the mechanism underlying this phenomenon, we demonstrate that the loss of functional CD4+ T lymphocytes during primary SIVmac251 infection is associated with both a selective depletion of memory CD4+ T cells and a loss of the functional capacity of the memory CD4+ T lymphocytes that escape viral destruction.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-10395840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-10590091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-11242051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-11559831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-11740186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-11751943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-12149221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-12496434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-12594515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-12663776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-12690201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-12942084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-14512540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-14676302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-14764720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-14978142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15090825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15220422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15300249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15545355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15793562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15793563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-15814700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-16709858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-16763152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-17047153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-17093193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-9545219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17522197-9858506
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8009-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17522197-Animals,
pubmed-meshheading:17522197-CD4 Lymphocyte Count,
pubmed-meshheading:17522197-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17522197-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17522197-Gene Products, gag,
pubmed-meshheading:17522197-HIV,
pubmed-meshheading:17522197-Humans,
pubmed-meshheading:17522197-Immunologic Memory,
pubmed-meshheading:17522197-Macaca mulatta,
pubmed-meshheading:17522197-RNA, Viral,
pubmed-meshheading:17522197-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:17522197-Simian immunodeficiency virus,
pubmed-meshheading:17522197-T-Lymphocyte Subsets
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pubmed:year |
2007
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pubmed:articleTitle |
Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection.
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pubmed:affiliation |
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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