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rdf:type |
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lifeskim:mentions |
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0080202,
umls-concept:C0205245,
umls-concept:C0237401,
umls-concept:C0242656,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C1880177,
umls-concept:C2362651,
umls-concept:C2745888,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2007-6-25
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pubmed:abstractText |
Using a dual color ELISPOT assay able to detect HIV-specific IFN-gamma, IL-2 and dual IFN-gamma/IL-2 secreting lymphocytes we screened for HIV peptide-specific responses directed against the entire HIV proteome in two groups of untreated HIV-infected individuals, slow progressors (SP) and progressors. We found that the three functional lymphocyte subsets contributed differentially to individual HIV peptide-specific responses within a study subject. Among the identified stimulatory peptides, a higher proportion induced dual IFN-gamma/IL-2 secretion in SP than progressors. While the magnitude of single IFN-gamma secreting lymphocytes is similar between groups, the magnitude of peptide-specific dual IFN-gamma/IL-2 secreting lymphocytes is significantly more intense in SP. Neither single nor total IFN-gamma secreting cell magnitude and breadth measurements correlated with CD4 cell count or viral load whereas both parameters of dual IFN-gamma/IL-2 secreting responses correlated positively with CD4 counts and negatively with viremia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1521-6616
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pubmed:author |
pubmed-author:BernardNicole FNF,
pubmed-author:BoulasselMohamed RMR,
pubmed-author:BouletSalixS,
pubmed-author:CôtéPierreP,
pubmed-author:FalutzJulianJ,
pubmed-author:LongpréDanièleD,
pubmed-author:NdongalaMichel LML,
pubmed-author:PeretzYoavY,
pubmed-author:RouleauDanielleD,
pubmed-author:RoutyJean-PierreJP,
pubmed-author:SékalyRafick PRP,
pubmed-author:TremblayCécileC,
pubmed-author:TsoukasChristos MCM
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-68
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17521962-Antigens, Viral,
pubmed-meshheading:17521962-CD4 Lymphocyte Count,
pubmed-meshheading:17521962-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17521962-Cells, Cultured,
pubmed-meshheading:17521962-Chronic Disease,
pubmed-meshheading:17521962-Disease Progression,
pubmed-meshheading:17521962-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17521962-Female,
pubmed-meshheading:17521962-HIV,
pubmed-meshheading:17521962-HIV Infections,
pubmed-meshheading:17521962-HIV Long-Term Survivors,
pubmed-meshheading:17521962-Humans,
pubmed-meshheading:17521962-Interferon-gamma,
pubmed-meshheading:17521962-Interleukin-2,
pubmed-meshheading:17521962-Lymphocyte Activation,
pubmed-meshheading:17521962-Male,
pubmed-meshheading:17521962-Middle Aged,
pubmed-meshheading:17521962-Peptides,
pubmed-meshheading:17521962-T-Lymphocyte Subsets,
pubmed-meshheading:17521962-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:17521962-Viral Load
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pubmed:year |
2007
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pubmed:articleTitle |
Functional T cell subsets contribute differentially to HIV peptide-specific responses within infected individuals: correlation of these functional T cell subsets with markers of disease progression.
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pubmed:affiliation |
Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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