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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1992-1-27
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pubmed:abstractText |
The culture of hepatocytes dissociated from adult mice by the collagenase perfusion method enables neurons or neuronal tissues to be cultured with hepatocytes or in hepatocyte-conditioned media. Co-culture with hepatocytes or hepatocyte-conditioned media enhances neurite regeneration and their survival from nerve-transected terminals of dorsal root ganglia with nerve fibers dissected from adult and aged mice. Hepatocytes secrete a factor which enhances not only neurite regeneration but also neurite survival. Activities of other known neurotrophic factors were not as crucial as those of the hepatocyte-conditioned medium, suggesting that this factor may differ from other trophic ones.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
521-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1751807-Age Factors,
pubmed-meshheading:1751807-Animals,
pubmed-meshheading:1751807-Axons,
pubmed-meshheading:1751807-Cells, Cultured,
pubmed-meshheading:1751807-Culture Media,
pubmed-meshheading:1751807-Fibroblast Growth Factor 2,
pubmed-meshheading:1751807-Ganglia, Spinal,
pubmed-meshheading:1751807-Growth Substances,
pubmed-meshheading:1751807-Heat-Shock Proteins,
pubmed-meshheading:1751807-Insulin,
pubmed-meshheading:1751807-Liver,
pubmed-meshheading:1751807-Mice,
pubmed-meshheading:1751807-Mice, Inbred C57BL,
pubmed-meshheading:1751807-Molecular Weight,
pubmed-meshheading:1751807-Nerve Growth Factors,
pubmed-meshheading:1751807-Nerve Regeneration,
pubmed-meshheading:1751807-Organ Culture Techniques,
pubmed-meshheading:1751807-Somatomedins
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pubmed:year |
1991
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pubmed:articleTitle |
Hepatocytes enhance neurite regeneration and survival from transected nerve terminals.
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pubmed:affiliation |
Department of Physiology, School of Medicine, Yokohama City University, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study
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