Source:http://linkedlifedata.com/resource/pubmed/id/17516293
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-5-22
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| pubmed:abstractText |
Mitochondrial uncoupling contributes to the control of energy expenditure. The brown fat specific uncoupling protein 1 (UCP1) mRNA was detected in intraperitoneal and extraperitoneal adipose tissue in adult humans. The A-3826G polymorphism in the UCP1 gene promoter region was found to be associated with reduced mRNA expression indicating that the polymorphism is of functional importance. OBJECTIVE: To determine allelic frequencies and genotypic distribution of the A-3826G polymorphism and to study its possible association with anthropometric parameters and biochemical markers of glucose and lipid metabolism in type 2 diabetes mellitus (DM2) patients (n=295), in offspring of DM2 patients (n=113), and in healthy adults without family history of DM2 (n=120). RESULTS AND DISCUSSION: In the whole cohort of 528 subjects, the G allele was observed with a frequency of 0.26. Genotypic distribution did not differ between diabetics and controls. However, in the offspring of DM2 patients, significantly higher BMI and a trend towards higher waist to hip ratio, waist to height ratio, waist circumference, and subcutaneous fat mass was observed in the AG genotype compared with the wild-type. Similar tendency was evident in the control group. This indicates possible involvement of the A-3826G polymorphism in the regulation of body composition.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0947-7349
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
115
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
303-7
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| pubmed:meshHeading |
pubmed-meshheading:17516293-Adult,
pubmed-meshheading:17516293-Adult Children,
pubmed-meshheading:17516293-Aged,
pubmed-meshheading:17516293-Body Composition,
pubmed-meshheading:17516293-Body Mass Index,
pubmed-meshheading:17516293-Czech Republic,
pubmed-meshheading:17516293-Diabetes Mellitus, Type 2,
pubmed-meshheading:17516293-Female,
pubmed-meshheading:17516293-Gene Frequency,
pubmed-meshheading:17516293-Genotype,
pubmed-meshheading:17516293-Glucose Intolerance,
pubmed-meshheading:17516293-Humans,
pubmed-meshheading:17516293-Insulin Resistance,
pubmed-meshheading:17516293-Ion Channels,
pubmed-meshheading:17516293-Lipid Metabolism,
pubmed-meshheading:17516293-Male,
pubmed-meshheading:17516293-Middle Aged,
pubmed-meshheading:17516293-Mitochondrial Proteins,
pubmed-meshheading:17516293-Polymorphism, Single Nucleotide
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
The UCP1 gene polymorphism A-3826G in relation to DM2 and body composition in Czech population.
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| pubmed:affiliation |
Institute of Endocrinology, Prague, Czech Republic. dsramkova@endo.cz
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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