Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-5-22
pubmed:abstractText
Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) is the only known enzyme able to reduce lipid peroxides bound to cell membranes. Moreover it has been involved in apoptosis and can influence intracellular signaling. To investigate the possible relationship between PHGPx and human cancer we have quantified PHGPx expression levels by real-time quantitative PCR and immunohistochemistry in tissue samples of human breast invasive ductal carcinoma from 34 patients compared with their own controls of benign breast tissue. PHGPx expression levels were compared with the clinical and pathological data of these patients. The results showed that PHGPx expression levels are downregulated in poorly differentiated (grade 3) breast invasive ductal carcinoma (P = 0.0043). PHGPx expression levels decreased gradually with tumor grade from grade 1 to grade 3. We also found a downregulation of PHGPx in cases that showed p53 accumulation compared with cases without p53 immunostaining (P = 0.0011). PHGPx was also downregulated in cases without progesterone receptors (PR) immunostaining compared with cases with PR immunostaining (P = 0.0165). Grade 3, p53 immunostaining and absence of PR immunostaining are poor prognostic factors. These results suggest that PHGPx downregulation could be related with a poorer prognosis in breast invasive ductal carcinoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1071-5762
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
681-7
pubmed:meshHeading
pubmed-meshheading:17516241-Adult, pubmed-meshheading:17516241-Aged, pubmed-meshheading:17516241-Breast Neoplasms, pubmed-meshheading:17516241-Carcinoma, Ductal, Breast, pubmed-meshheading:17516241-Cell Differentiation, pubmed-meshheading:17516241-Down-Regulation, pubmed-meshheading:17516241-Female, pubmed-meshheading:17516241-Gene Expression Regulation, Enzymologic, pubmed-meshheading:17516241-Glutathione Peroxidase, pubmed-meshheading:17516241-Humans, pubmed-meshheading:17516241-Immunoenzyme Techniques, pubmed-meshheading:17516241-Middle Aged, pubmed-meshheading:17516241-RNA, Messenger, pubmed-meshheading:17516241-RNA, Neoplasm, pubmed-meshheading:17516241-Receptors, Estrogen, pubmed-meshheading:17516241-Receptors, Progesterone, pubmed-meshheading:17516241-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17516241-Tumor Markers, Biological, pubmed-meshheading:17516241-Tumor Suppressor Protein p53
pubmed:year
2007
pubmed:articleTitle
Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma.
pubmed:affiliation
Medical Oncology Service, Hospital Universitario La Paz, Madrid, Spain.
pubmed:publicationType
Journal Article