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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7147
pubmed:dateCreated
2007-6-21
pubmed:databankReference
pubmed:abstractText
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1476-4687
pubmed:author
pubmed-author:DePinhoRonald ARA, pubmed-author:RoweJacob MJM, pubmed-author:StrattonMichael RMR, pubmed-author:GoldstoneAnthony HAH, pubmed-author:ChinLyndaL, pubmed-author:ForoniLetiziaL, pubmed-author:MansourMarcM, pubmed-author:FieldingAdele KAK, pubmed-author:FutrealP AndrewPA, pubmed-author:LookA ThomasAT, pubmed-author:MartinEric SES, pubmed-author:AsterJonJ, pubmed-author:ProtopopovAlexeiA, pubmed-author:EdkinsSarahS, pubmed-author:StevensClaireC, pubmed-author:JiangShanS, pubmed-author:MaserRichard SRS, pubmed-author:LinEricE, pubmed-author:ChoudhuryBhudipaB, pubmed-author:WiedemeyerRuprechtR, pubmed-author:WongKwok-KinKK, pubmed-author:IvanovaElenaE, pubmed-author:KabbarahOmarO, pubmed-author:O'NeilJenniferJ, pubmed-author:CampbellPeter JPJ, pubmed-author:FengBinB, pubmed-author:DukeVeroniqueV
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