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rdf:type |
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lifeskim:mentions |
umls-concept:C0003993,
umls-concept:C0003997,
umls-concept:C0007600,
umls-concept:C0023449,
umls-concept:C0033684,
umls-concept:C0035696,
umls-concept:C0036667,
umls-concept:C0312418,
umls-concept:C0456205,
umls-concept:C1550605,
umls-concept:C1707520
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2007-12-12
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|
pubmed:abstractText |
Asparaginase (ASNase) is an essential component of most treatment protocols for childhood acute lymphoblastic leukemia (ALL). Although increased asparagine synthetase (ASNS) expression may contribute to ASNase resistance, there is conflicting data from patient samples with regard to correlation between ASNS mRNA content and ASNase sensitivity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1545-5017
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|
pubmed:author |
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pubmed:copyrightInfo |
(c) 2007 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
274-9
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pubmed:dateRevised |
2009-1-12
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pubmed:meshHeading |
pubmed-meshheading:17514734-Antineoplastic Agents,
pubmed-meshheading:17514734-Asparaginase,
pubmed-meshheading:17514734-Aspartate-Ammonia Ligase,
pubmed-meshheading:17514734-Cell Line, Tumor,
pubmed-meshheading:17514734-Dose-Response Relationship, Drug,
pubmed-meshheading:17514734-Drug Resistance, Neoplasm,
pubmed-meshheading:17514734-Drug Screening Assays, Antitumor,
pubmed-meshheading:17514734-Humans,
pubmed-meshheading:17514734-Infant,
pubmed-meshheading:17514734-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:17514734-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17514734-RNA, Messenger
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines.
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|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, University of Florida Shands Cancer Center, University of Florida College of Medicine, Gainesville, Florida, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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