Linked Life Data

17514716

Source:http://linkedlifedata.com/resource/pubmed/id/17514716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2007-7-16
pubmed:abstractText
Phosphoinositides (PPIn) form a unique family of lipids derived by phosphorylation of the parent compound, phosphatidylinositol. Despite being minor constituents of synaptic membranes, these lipids have exceptionally high rates of metabolic turnover and are involved with myriad aspects of pre- and post-synaptic function, from the control of the synaptic vesicle cycle to postsynaptic excitability. In this review, we outline the main synaptic processes known to be regulated by these molecules, focusing mainly but not exclusively on the major species phosphatidylinositol 4-phosphate and phosphatidylinositol (4,5)-bisphosphate. Furthermore, we discuss the enzymes responsible for their synthesis and degradation, with a view to exploring how the activity-dependent control of their enzymatic action can lead to the precise regulation of PPIn levels at the nerve terminal. Also, the modulation of synaptic PPIn turnover by drugs used for the treatment of bipolar disorder is discussed. We propose that the modulation of PPIn levels may act as a central mechanism to coordinate the cascade of synaptic events leading to neurotransmission.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1932-8451
pubmed:author
pubmed:copyrightInfo
(c) 2007 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1232-47
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Polyphosphoinositol lipids: under-PPInning synaptic function in health and disease.
pubmed:affiliation
Molecular NeuroPathobiology, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, London WC2A 3PX, United Kingdom. gruh2@cam.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't