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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1976-4-9
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pubmed:abstractText |
An infant with severe combined immunodeficiency had normal numbers of lymphocytes which bore E rosette and surface Ig markers in an appropriate distribution. However, only minimal responsivity to in vitro stimulation by mitogens and allogenic cells, and none to antigens could be elicited; functional antibody responses were also nil, except to cytomegalovirus. Intrauterine-acquired cytomegalovirus may have caused his immune dysfunction, although the possibility of a postnatal infection cannot be excluded. Therapy with transfer factor and thymus transplantation was unsucessful in restoring immunity and may have aggravated a pre-existing monoclonal gammopathy. It is possible that the monoclonal protein was derived from B-cells transplacentally received from the patients mother.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0022-3476
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
217-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:175143-Antibody Formation,
pubmed-meshheading:175143-Antigens,
pubmed-meshheading:175143-Chronic Disease,
pubmed-meshheading:175143-Cytomegalovirus Infections,
pubmed-meshheading:175143-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:175143-Erythrocytes,
pubmed-meshheading:175143-Humans,
pubmed-meshheading:175143-Hypergammaglobulinemia,
pubmed-meshheading:175143-Immune Adherence Reaction,
pubmed-meshheading:175143-Immunoglobulin G,
pubmed-meshheading:175143-Immunologic Deficiency Syndromes,
pubmed-meshheading:175143-Infant,
pubmed-meshheading:175143-Infant, Newborn,
pubmed-meshheading:175143-Lymphocytes,
pubmed-meshheading:175143-Mitogens,
pubmed-meshheading:175143-Skin Tests
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pubmed:year |
1976
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pubmed:articleTitle |
Chronic cytomegalovirus infection, immunodeficiency, and monoclonal gammopathy-antigen-driven malignancy?
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|