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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
2007-7-2
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pubmed:abstractText |
Osteoporosis is a major public health problem and the most obvious preventive strategy, hormone replacement therapy, has lost favor due to recent findings of the Women's Health Initiative regarding increased risks of breast cancer and cardiovascular disease. Resveratrol, a naturally occurring compound possessing estrogenic activity, is thought to have considerable potential for therapy of osteoporosis. In the present study, resveratrol was found to exhibit bone-protective effects equivalent to those exerted by hormone replacement therapy and decrease the risk of breast cancer in the in vivo and in vitro models. Forkhead proteins were found to be essential for both effects of resveratrol. The bone-protective effect was attributable to induction of bone morphogenetic protein-2 through Src kinase-dependent estrogen receptor activation and FOXA1 is required for resveratrol-induced estrogen receptor-dependent bone morphogenetic protein-2 expression. The tumor-suppressive effects of resveratrol were the consequence of Akt inactivation-mediated FOXO3a nuclear accumulation and activation. Resveratrol is therefore anticipated to be highly effective in management of postmenopausal osteoporosis without an increased risk of breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Stilbenes,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/resveratrol,
http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
282
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19385-98
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17513867-Animals,
pubmed-meshheading:17513867-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17513867-Bone Morphogenetic Protein 2,
pubmed-meshheading:17513867-Bone Morphogenetic Proteins,
pubmed-meshheading:17513867-Breast Neoplasms,
pubmed-meshheading:17513867-Cell Line, Tumor,
pubmed-meshheading:17513867-Estrogen Replacement Therapy,
pubmed-meshheading:17513867-Estrogens,
pubmed-meshheading:17513867-Female,
pubmed-meshheading:17513867-Forkhead Transcription Factors,
pubmed-meshheading:17513867-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17513867-Humans,
pubmed-meshheading:17513867-Mice,
pubmed-meshheading:17513867-Osteoporosis, Postmenopausal,
pubmed-meshheading:17513867-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17513867-Receptors, Estrogen,
pubmed-meshheading:17513867-Risk Factors,
pubmed-meshheading:17513867-Stilbenes,
pubmed-meshheading:17513867-Transforming Growth Factor beta,
pubmed-meshheading:17513867-src-Family Kinases
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pubmed:year |
2007
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pubmed:articleTitle |
Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol.
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pubmed:affiliation |
Graduate Institute of Cancer Biology, College of Medicine, China Medical University, Taichung 404, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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