Linked Life Data

17513730

Source:http://linkedlifedata.com/resource/pubmed/id/17513730

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2007-5-21
pubmed:abstractText
We previously characterized several tumor-specific T cell clones from PBL and tumor-infiltrating lymphocytes of a lung cancer patient with identical TCR rearrangements and similar lytic potential, but with different antitumor response. A role of the TCR inhibitory molecule CD5 to impair reactivity of peripheral T cells against the tumor was found to be involved in this process. In this report, we demonstrate that CD5 also controls the susceptibility of specific T cells to activation-induced cell death (AICD) triggered by the tumor. Using a panel of tumor-infiltrating lymphocytes and PBL-derived clones expressing different levels of CD5, our results indicate that T lymphocyte AICD in response to the cognate tumor is inversely proportional to the surface expression level of CD5. They also suggest a direct involvement of CD5 in this process, as revealed by an increase in tumor-mediated T lymphocyte AICD following neutralization of the molecule with specific mAb. Mechanistically, our data indicate that down-regulation of FasL expression and subsequent inhibition of caspase-8 activation are involved in CD5-induced T cell survival. These results provide evidence for a role of CD5 in the fate of peripheral tumor-specific T cells and further suggest its contribution to regulate the extension of CTL response against tumor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6821-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17513730-Antigens, CD5, pubmed-meshheading:17513730-Antigens, Neoplasm, pubmed-meshheading:17513730-Caspase 8, pubmed-meshheading:17513730-Cell Death, pubmed-meshheading:17513730-Cell Line, Tumor, pubmed-meshheading:17513730-Cell Survival, pubmed-meshheading:17513730-Cytotoxicity, Immunologic, pubmed-meshheading:17513730-Enzyme Activation, pubmed-meshheading:17513730-Epitopes, T-Lymphocyte, pubmed-meshheading:17513730-Fas Ligand Protein, pubmed-meshheading:17513730-Humans, pubmed-meshheading:17513730-Jurkat Cells, pubmed-meshheading:17513730-Lung Neoplasms, pubmed-meshheading:17513730-Lymphocyte Activation, pubmed-meshheading:17513730-Lymphocytes, Tumor-Infiltrating, pubmed-meshheading:17513730-Neoplastic Cells, Circulating, pubmed-meshheading:17513730-T-Lymphocytes, Cytotoxic
pubmed:year
2007
pubmed:articleTitle
Human CD5 protects circulating tumor antigen-specific CTL from tumor-mediated activation-induced cell death.
pubmed:affiliation
Laboratoire "Immunologie des tumeurs humaines: Interaction effecteurs cytotoxiques-système tumoral," Institut National de la Santé et de la Recherche Médicale Unité 753, Institut Fédératif de Recherche 54, Institut Gustave Roussy, Villejuif, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't