Source:http://linkedlifedata.com/resource/pubmed/id/17513634
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0030685,
umls-concept:C0073379,
umls-concept:C0205263,
umls-concept:C0220839,
umls-concept:C0231441,
umls-concept:C0234156,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0871261,
umls-concept:C1283071,
umls-concept:C1517945,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1948023,
umls-concept:C1963578,
umls-concept:C1999216,
umls-concept:C2911692
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| pubmed:issue |
6
|
| pubmed:dateCreated |
2007-5-21
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| pubmed:abstractText |
The general anesthetic state comprises behavioral and perceptual components, including amnesia, unconsciousness, analgesia, and immobility. In vitro, glutamatergic excitatory neurons are important targets for anesthetic action at the cellular and microcircuits levels. Riluzole (2-amino-6-[trifluoromethoxy]benzothiazole) is a neuroprotective drug that inhibits glutamate release from nerve terminals in the central nervous system. Here, we examined in vivo the ability of riluzole to produce components of the general anesthetic state through a selective blockade of glutamatergic neurotransmission.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
|
| pubmed:issn |
1526-7598
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
104
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1415-21, table of contents
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| pubmed:meshHeading |
pubmed-meshheading:17513634-Analgesics,
pubmed-meshheading:17513634-Animals,
pubmed-meshheading:17513634-Dose-Response Relationship, Drug,
pubmed-meshheading:17513634-Glutamic Acid,
pubmed-meshheading:17513634-Immobilization,
pubmed-meshheading:17513634-Male,
pubmed-meshheading:17513634-Mice,
pubmed-meshheading:17513634-Movement,
pubmed-meshheading:17513634-Pain,
pubmed-meshheading:17513634-Pain Measurement,
pubmed-meshheading:17513634-Physical Stimulation,
pubmed-meshheading:17513634-Reflex,
pubmed-meshheading:17513634-Riluzole
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| pubmed:year |
2007
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| pubmed:articleTitle |
Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice.
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| pubmed:affiliation |
Department of Dental Anesthesiology, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. mirifun@hiroshima-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|