Source:http://linkedlifedata.com/resource/pubmed/id/17513507
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2007-12-24
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pubmed:abstractText |
Gastric cancer is one of the major causes of cancer-related death worldwide. Familial clustering is observed in about 10% of cases; 1-3% of cases are hereditary. In the latter group, a syndrome which has been well characterised is hereditary diffuse gastric cancer; this is specifically associated with CDH1 (E-cadherin) germline mutations in about 30% of families. In this article, the state of the art of familial gastric cancer regarding the clinical, molecular and pathology features is reviewed, as well as the practical aspects for a correct diagnosis and clinical management.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1472-4146
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-30
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pubmed:meshHeading |
pubmed-meshheading:17513507-Cadherins,
pubmed-meshheading:17513507-Germ-Line Mutation,
pubmed-meshheading:17513507-Humans,
pubmed-meshheading:17513507-Mass Screening,
pubmed-meshheading:17513507-Mutation, Missense,
pubmed-meshheading:17513507-Neoplasm Proteins,
pubmed-meshheading:17513507-Neoplastic Syndromes, Hereditary,
pubmed-meshheading:17513507-Stomach Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer.
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pubmed:affiliation |
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal. fcarneiro@ipatimup.pt
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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