Linked Life Data

17512804

Source:http://linkedlifedata.com/resource/pubmed/id/17512804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-6-25
pubmed:abstractText
The impact of sickle cell anaemia (SCA) on respiratory function of children must be determined if their management is to be optimised. Pulmonary diffusing capacity (DL(CO)), corrected for haemoglobin (DL(COc)), therefore was assessed in 24 children with SCA and 24 ethnic matched controls, mean age 11 (range 7-16) years. To determine if any differences found correlated with other measures of lung function, spirometry was undertaken and lung volumes assessed. The SCA children compared to the controls had lower weight (p=0.01), body mass index (p=0.002), DL(CO) (p<0.0001), K(CO) (p=0.003), V(CSB) (p=0.01), FEV(1) (p<0.0001) and FVC (p<0.0001), but greater K(COc) (p=0.001). K(COc) results correlated significantly with PEF (r=-0.58, p=0.02), but not TLC(pleth) (p=0.36), FEV(1) (0.39) or FVC (p=0.36). In conclusion, when corrected for haemoglobin levels, the SCA children compared to controls of similar age had elevated gas transfer per unit lung volume results. Our results suggest this abnormality is independent of other lung function abnormalities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1569-9048
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
158
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-4
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Lung gas transfer in children with sickle cell anaemia.
pubmed:affiliation
King's College London, MRC-Asthma Centre, Division of Asthma, Allergy and Lung Biology, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't