Linked Life Data

17512533

Source:http://linkedlifedata.com/resource/pubmed/id/17512533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-6-15
pubmed:abstractText
CpG oligodeoxynucleotides are potent immunostimulants. For parenterally delivered alum-based vaccines, the immunostimulatory effect of CpG depends on the association of the CpG and antigen to the alum. We describe effects of buffer components on the binding of CPG 7909 to aluminum hydroxide (Alhydrogel), assays for measuring binding of CPG 7909 to alum and CPG 7909 induced dissociation of antigen from the alum. Free CPG 7909 is a potent inducer of IP-10 in mice. However the lack of IP-10 production from formulations containing bound CPG 7909 suggested that CPG 7909 does not rapidly dissociate from the alum after injection. It also suggests that IP-10 assays are not a good basis for potency assays for alum-based vaccines containing CPG 7909.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-10640783, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-10940883, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-12058646, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-12071703, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-12438374, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-12450702, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-12665200, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-12682235, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-14638762, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-15233736, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-15534490, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-15694511, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-15837212, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-15908397, http://linkedlifedata.com/resource/pubmed/commentcorrection/17512533-16434128
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-1759
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
323
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-46
pubmed:dateRevised
2011-9-19
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Formulation of vaccines containing CpG oligonucleotides and alum.
pubmed:affiliation
Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD, 20852 USA. jaebig@niaid.nih.gov <jaebig@niaid.nih.gov>
pubmed:publicationType
Journal Article, Research Support, N.I.H., Intramural